Drug Discovery Support
The Drug Discovery Support (DDS) team works closely with a research team of biologists and medicinal chemists to provide critical information on new chemical entities. The team provides key information on the biopharmaceutical properties of new entities. This includes solubility, permeability and metabolic stability. DDS also carefully considers the safety of the chemicals and how they will be distributed to target sites.
The DDS group is truly multidisciplinary, consisting of specialists in pharmaceutics, pharmacology and pharmacokinetics (PK), including drug absorption, distribution, metabolism and excretion (ADME). Using state-of-the-art robotic stations and highly sensitive bioanalytical methods based on mass spectrometry, this group conducts high-throughput ADME-PK trials with high sensitivity and data accuracy. The research team is given integrated data analysis and interpretation which helps them understand the relationships between structural and biological properties of drug candidates. With such excellent interdisciplinary support, the researchers can then build models that will predict more accurately the biological properties of future compounds. The recently renovated pharmaceutics laboratory is equipped to perform X-ray powder diffraction, dissolution and stability studies and allows the DDS group to perform early solid-form characterization, salt form selection, and data-driven formulation design.
.
